A team of cardiovascular scientists has announced it
will be able to 3D print a whole heart from the recipients' own cells within a
decade.
Stuart K Williams is heading up the hugely ambitious
project as executive and scientific director of the Cardiovascular
Innovation Institute at the University of Louisville.
Throughout his prestigious career spanning four
decades he has focused on researching surgical devices and bioengineering, and
the idea for printing the heart whole from scratch was inspired by the work of
one of the pioneers in both these fields -- Charles Lindbergh.
Lindbergh might be best known for flying solo across
the Atlantic and for the Crime of the Century (when his infant son was
kidnapped and murdered) but he also created a glass perfusion pump with Alexia
Carrel that would keep the human heart alive outside the body, paving the way
for heart surgery. The pair also discussed regenerative medicine in their book The
Culture of Organs.
"For bio-printing it is the end of the
beginning as bio-printed structures are now under intense study by
biologists" Stuart K Williams, Cardiovascular Innovation Institute
"Funding is very limited as this is a new area.
But as bio-printing successes occur the interest will increase and then funding
-- so many breakthroughs have occurred in this way with a new untested idea
that is moved forward with limited resources. For bio-printing it is the end of
the beginning as bio-printed structures are now under intense study by
biologists."
Williams says he and his team of more than 20 have
already bioengineered a coronary artery and printed the smallest blood vessels
in the heart used in microcirculation. The team has also worked on other
methods of bioengineering tissue, including electro-spinning for the creation
of large blood vessel scaffolds that can then be joined with bio-printed micro-vessels.
But why print the parts, when you can print the
whole in one go? We shouldn't just be able to repair the heart using
bioengineering, but replace it.
The Cardiovascular Innovation Institute is now
developing 3D printers for the job with a team of engineers and vascular
biologists -- "if you do not understand the biology, you solve only half
the problem" explains Williams.
Though for now those printers are focusing on
replicating the parts, the plan is to print the whole in one go in just three
hours, with a further week needed for it to mature outside of the body. Certain
parts will need to be printed and assembled beforehand, including the valves
and the biggest blood vessels. "Final construction will then be achieved
by bio-printing and strategic placement of the valves and big vessels,"
says Williams, who asserts that they are "on schedule" to build the heart
within the decade marker.
"Dare I say the heart is one of the easiest to
bio-print? It's just a pump with tubes you need to connect" Stuart K Williams, Cardiovascular
Innovation Institute
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